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Needle reuse can cause dulling and barb formation, significantly increasing injection pain

Notably, the age-related increases in nitration of ECM-bound HGF were predominant on fast IIa and IIx myofibers 32 , corresponding with the fast fiber-preference observed in age-related muscle atrophy and impaired regeneration in humans in which fast IIb fibers are scarce 33,34,35, 39

A lot of the studies: Are small Have a high risk for bias (poor reporting/inconsistency/blinding/etc) Show mixed results (heterogeneity) Often the studies arent even looking at the same thing: One study might look at PCOS patients, another at endometriosis patients Another might use 800 ug of folate instead of 400 ug Some might combine different supplements instead of just one So its hard to make strong conclusions

For Supplementary Fig